Gender dysphoria
Content warning: this article deals with heavy subject matter.
Gender dysphoria is when you get particularly depressed being on the wrong hormones and having to pretend to be the wrong gender.
While this most commonly affects transgender people, as we are most often in this situation, it affects cis people just as much on the rare occasions they're in the same situation.
As men generally don't like having gynecomastia (growing breasts), and women generally don't like having hirsutism (growing facial and body hair), regardless of whether they're trans or cis, it seems to be pretty universal that people don't like being on the wrong hormones. Even aside from its more visible effects, there are support groups for men who, in an attempt to stop balding, took antiandrogens and developed brain fog. Similarly, trans men and women who switch hormones benefit just as much from thinking clearer as we do from looking, sounding, smelling, and feeling more appropriate.
As far as having to pretend to be the wrong gender goes, this is an even rarer thing to happen to cis people, but still has terrible psychological effects. For example, author and cis lesbian Norah Vincent pretended to be a man for eighteen months, in order to write the undercover journalism book Self-Made Man. This gave her a depressive breakdown.
The combination of being on the wrong hormones and having to pretend to be the wrong gender was forced onto cis man David Reimer since he was an infant, in an attempt to cover up a botched circumcision, obviously with neither his knowledge nor his consent. He still innately knew he was male in spite of what his parents and doctors told him and did to his body. He changed sex back again, and ultimately ended up killing himself.
These are all generally recognised as tragic cases. Clearly, cis people generally have empathy towards other cis people in these situations. Many of them just need to learn to extend that empathy towards trans people (and, for that matter, other minorities), who are equally devastated by being in the same situations.
Gender: Dysmorphia and dysphoria | Gender dysphoria
